Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*:RPA1:RPA2:RPA3
Maps_Modules
dnarepair
dnarepair
References
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
d_re249( dnarepair ):
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process:
d_re139( dnarepair ):
PMID:19686080
POLH participates in the D-loop formation in HR:
PMID:16337602, PMID:16337601
Complex PolN:HEL308 participates in HR and in Fanconi PMID:19995904
d_re163( dnarepair ):
POLH activates D-loop extention
PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
Presence of FA core complex is essential for thePolZ/Rev1 activity:
PMID:18448394
PoLQ/HEL308 in Fancon:
PMID:18472307
d_re165( dnarepair ):
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
Confidence
REF=5 FUNC=4
Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*:RPA1:RPA2:RPA3
Maps_Modules
dnarepair
dnarepair
References
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
d_re249( dnarepair ):
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process:
Confidence
REF=4 FUNC=4
+ BRCA2@default + FANCJ*@default + RPA1:RPA2:RPA3@default + FANCN*@default + FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho@default → BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:FANCJ*:FANCN*:RPA1:RPA2:RPA3@default
→ BRCA1:BRCA2:FANCD2|pho:FANCI|pho:FANCJ*:FANCN*:RPA1:RPA2:RPA3@default