BRCA2

Protein BRCA2

Identifiers
breast cancer 2, early onset, FANCD1
HUGO:BRCA2 HGNC:1101 ENTREZ:675 UNIPROT:P51587 GENECARDS:BRCA2 REACTOME:50952 KEGG:675 ATLASONC:BRCA2ID164ch13q13 WIKI:BRCA2

Maps_Modules
dnarepair
dnarepair

References
For HR pathway
PMID:19772495, PMID:16697054, PMID:19847258
For Fanconi anemia pathway
PMID:19686080, PMID:19622404, PMID:18931676

BRCA2@default

References
d_re120( dnarepair ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
d_re166( dnarepair ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
d_re203( dnarepair ):
The complex activates HR
PMID:18212739

Modifications:
In compartment: default

BRCA2@default

Participates in complexes:
In compartment: default

Participates in reactions:
As Reactant or Product:

As Catalyser: