Protein HES1
Identifiers
hairy and enhancer of split 1, (Drosophila)
HUGO:HES1 HGNC:5192 ENTREZ:3280 UNIPROT:Q14469 GENECARDS:HES1 REACTOME:56466 KEGG:3280 ATLASONC:GC_HES1 WIKI:HES1
Maps_Modules
dnarepair
dnarepair
survival
References
PMID:8020957, PMID:12535671, PMID:12972610, PMID:18550849, PMID:20832754
FA core complex regulates REV1 and activated TLS
PMID:22266823
Modifications:
In compartment: default
- HES1@default
Participates in complexes:
In compartment: default
- BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1@default
- BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1:RPA1:RPA2:RPA3:TOP3A@default
Participates in reactions:
As Reactant or Product:- FANCA|pho:FANCG|S7_pho@default
+ FANCC:FANCE|S376_pho|T346_pho:FANCF@default
+ FAAP24*:FANCM@default
+ FAAP100*:FANCB:FANCL@default
+ BLM@Nucleus
+ HES1@default
+ FAAP20*@default
→
BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1@default
- BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1@default
+ TOP3A@default
+ RPA1:RPA2:RPA3@default
→
BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1:RPA1:RPA2:RPA3:TOP3A@default
As Catalyser:- gFanconi_DNA_st2*@Nucleus
→
gFanconi_DNA_st3*@Nucleus
- FANCD2|pho@default
→
FANCD2|K561_ubi|pho@default
- FANCI|pho@default
→
FANCI|K523_ubi|pho@default
- gFanconi_DNA_st4*@Nucleus
→
gFanconi_DNA_st5*@Nucleus
- FANCD2@default
→
FANCD2|pho@default
- FANCD2|K561_ubi|pho@default
+ MRE11*:NBS1*|S343_pho:RAD50@default
+ ATR|pho|active@Nucleus
→
ATR|pho:FANCD2|K561_ubi|pho:MRE11*:NBS1*|S343_pho:RAD50@default
- gTLS_DNA_st1*@Nucleus
→
gTLS_DNA_st2*@Nucleus