Complex IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2 map
Complex composition:

  1. TYK2 map
  2. JAK2 map
  3. IL4 map
  4. IL13RA1 map
  5. IL4R map
  6. JAK1 map


IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
CASCADE:IL4

References
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4Rα and common gamma-chain (IL-2Rγ);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:12223527
Type II IL-4 receptors associates with Jak1,JAK2 and TYK2
PMID:23124025
IL4 binding induces Jak1 phosphorylation (but not Jak2, JAK3, or TYK2).

IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
 MACROPHAGE  map
 MDSC  map
CASCADE:IL4


Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  2. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL13RA1:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  2. IL4@default map + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gTIMP3@INNATE_IMMUNE_CELL_Cytosol map map rTIMP3@INNATE_IMMUNE_CELL_Cytosol map
  2. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  3. gIL23A@INNATE_IMMUNE_CELL_Cytosol map map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  4. gIL18@INNATE_IMMUNE_CELL_Cytosol map map rIL18@INNATE_IMMUNE_CELL_Cytosol map
  5. gINHBA@INNATE_IMMUNE_CELL_Cytosol map map rINHBA@INNATE_IMMUNE_CELL_Cytosol map
  6. STAT6@INNATE_IMMUNE_CELL_Cytosol map map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map