Complex IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2
Complex composition:
- TYK2
- JAK2
- IL4
- IL13RA1
- IL4R
- JAK1
IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
Identifiers
NAME:IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2
Maps_Modules
MACROPHAGE
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
CASCADE:IL4
References
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4Rα and common gamma-chain (IL-2Rγ);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:12223527
Type II IL-4 receptors associates with Jak1,JAK2 and TYK2
PMID:23124025
IL4 binding induces Jak1 phosphorylation (but not Jak2, JAK3, or TYK2).
IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
Identifiers
NAME:IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2
Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
MACROPHAGE
MDSC
CASCADE:IL4
Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
- IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
- IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
Participates in reactions:
As Reactant or Product:- IL13RA1:IL4:IL4R@INNATE_IMMUNE_CELL_Membrane
+ JAK1|pho@INNATE_IMMUNE_CELL_Cytosol
+ TYK2@INNATE_IMMUNE_CELL_Cytosol
+ JAK2@INNATE_IMMUNE_CELL_Cytosol
→
IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
- IL4@default
+ IL13RA1:IL4R@INNATE_IMMUNE_CELL_Membrane
+ JAK1@INNATE_IMMUNE_CELL_Cytosol
+ JAK2@INNATE_IMMUNE_CELL_Cytosol
+ TYK2@INNATE_IMMUNE_CELL_Cytosol
→
IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
As Catalyser:- gTIMP3@INNATE_IMMUNE_CELL_Cytosol
→
rTIMP3@INNATE_IMMUNE_CELL_Cytosol
- gIL12p40*@INNATE_IMMUNE_CELL_Cytosol
→
rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
- gIL23A@INNATE_IMMUNE_CELL_Cytosol
→
rIL23A@INNATE_IMMUNE_CELL_Cytosol
- gIL18@INNATE_IMMUNE_CELL_Cytosol
→
rIL18@INNATE_IMMUNE_CELL_Cytosol
- gINHBA@INNATE_IMMUNE_CELL_Cytosol
→
rINHBA@INNATE_IMMUNE_CELL_Cytosol
- STAT6@INNATE_IMMUNE_CELL_Cytosol
→
STAT6|pho|active@INNATE_IMMUNE_CELL_Cytosol