IL4

Protein IL4

Identifiers
HUGO:IL4

Maps_Modules
MACROPHAGE
MDSC
DENDRITIC_CELL
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
MODULE:EFFECTOR_INHIBITION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION
CASCADE:IL4
CASCADE:Fc_gamma_RIII

References
PMID:12401408
IL4 is assosiated with M2 polarization of macrophages
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4Rα and common gamma-chain (IL-2Rγ);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:12496409
Arg1 is up-regulated in MDSC by IL-4.
Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS), and that superoxide is required for Arg1-dependent suppression of T cell function.
PMID:18250477
LIL-4 or IL-13 stimulated the release of galectin-3
into the culture media in both BMDMs and PBMs.
PMID:11870632, PMID:9834059
Stimulation of NK cells with IL-4 inhibited IFN-gamma, but increased IL5, IL-13 production.
NK cells stimuletad by IL4 have NK2 subtype ()

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

IL4@INNATE_IMMUNE_CELL_Cytosol

In compartment: default

IL4@default

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: