Complex TGFB*:TGFBR1:TGFBR2 map
Complex composition:

  1. TGFBR1 map
  2. TGFBR2 map
  3. TGFB* map

TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:TGFB*:TGFBR1:TGFBR2

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:TGFB
11792802, 12809600
The canonical TGFB signalling pathway involves phosphorylation of the carboxy-terminal serine residue of the internal modulator SMAD proteins,
SMAD2 or SMAD3, by the activated receptors. This phosphorylation induces oligomerization of SMAD2 or SMAD3 with SMAD4, which is necessary for nuclear translocation

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TGFBR1@INNATE_IMMUNE_CELL_Membrane map + TGFBR2@INNATE_IMMUNE_CELL_Membrane map + TGFB*@default map → map TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gCCL5@INNATE_IMMUNE_CELL_Cytosol map → map rCCL5@INNATE_IMMUNE_CELL_Cytosol map
  2. SMAD3@INNATE_IMMUNE_CELL_Cytosol map → map SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. SMAD2@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map
  5. gCCL3@INNATE_IMMUNE_CELL_Cytosol map → map rCCL3@INNATE_IMMUNE_CELL_Cytosol map
  6. gCCL2@INNATE_IMMUNE_CELL_Cytosol map → map rCCL2@INNATE_IMMUNE_CELL_Cytosol map