Protein TGFBR2 map

Identifiers
HUGO:TGFBR2

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
CASCADE:TGFB

References
PMID:24132110
TGFB1, TGFB2, TGFB3 ligands bind to the type 2 TGFβ receptor (TGFBR2), which causes recruitment and phosphorylation of TGFBR1, resulting in downstream signalling activation.
PMID:22703233
TGFBR2 upregulates expression of markers M2 activation as ARG1, MCR2 and LGALS3 (galecsin3) and induces AKT activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TGFBR2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TGFBR1@INNATE_IMMUNE_CELL_Membrane map + TGFBR2@INNATE_IMMUNE_CELL_Membrane map + TGFB*@default map → map TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane map
  2. rTGFBR2@INNATE_IMMUNE_CELL_Cytosol map → map TGFBR2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gLGALS3@INNATE_IMMUNE_CELL_Cytosol map → map rLGALS3@INNATE_IMMUNE_CELL_Cytosol map
  2. gMRC2@MARKERS_MACROPHAGE map → map rMRC2@MARKERS_MACROPHAGE map
  3. gCCL5@INNATE_IMMUNE_CELL_Cytosol map → map rCCL5@INNATE_IMMUNE_CELL_Cytosol map
  4. AKT*@INNATE_IMMUNE_CELL_Cytosol map → map AKT*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. SMAD3@INNATE_IMMUNE_CELL_Cytosol map → map SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. SMAD2@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  7. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map
  8. gCCL3@INNATE_IMMUNE_CELL_Cytosol map → map rCCL3@INNATE_IMMUNE_CELL_Cytosol map
  9. gCCL2@INNATE_IMMUNE_CELL_Cytosol map → map rCCL2@INNATE_IMMUNE_CELL_Cytosol map