Protein SMAD3 map

Identifiers
HUGO:SMAD3

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:TGFB
PMID:11792802, PMID:12809600
The canonical TGFB signalling pathway involves phosphorylation of the carboxy-terminal serine residue of the internal modulator SMAD proteins, SMAD2 or SMAD3, by the activated receptors. This phosphorylation induces oligomerization of SMAD2 or SMAD3 with SMAD4, which is necessary for nuclear translocation.
PMID:18768831
TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells.
SMAD3 downstream of TGFB inhibits expression TBX21 (T-BET). TBX21 is involeved in IFNG gene activation.
PMID:16713975
TGF-β signaling could target IFNG gene expression via TBX21 (TBET) and in a SMAD-dependent fashion that is independent of T-BET.
SMAD3 can directly interact with IFNG promoter.
PMID:21042762
Inhibition of TGF-ß signalinginduced phenotypic maturation of BM-DCs and human DCs and improved their abilities to produce IL-12 in a dose-dependent manner via SMADs.
PMID:22331441
Smad2/3 inhibited IFN-β production by suppressing IRF3 transcriptional activity.
Smad2/3 somehow suppresses IRF3 phosphorylation in macrophages
Smad2 and Smad3 negatively regulate iNOS induction in macrophages by suppressing multiple steps in the IRF3-IFN-β-STAT1 pathway

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SMAD3@INNATE_IMMUNE_CELL_Cytosol map
  2. SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SMAD3|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SMAD3@INNATE_IMMUNE_CELL_Cytosol map → map SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol map + SMAD4@INNATE_IMMUNE_CELL_Cytosol map → map SMAD3|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
  3. rSMAD3@INNATE_IMMUNE_CELL_Cytosol map → map SMAD3@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IL12*@INNATE_IMMUNE_CELL_Cytosol map → map IL12*@default map
  2. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  3. gARG1@INNATE_IMMUNE_CELL_Cytosol map → map rARG1@INNATE_IMMUNE_CELL_Cytosol map
  4. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
  5. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
  6. IRF3@INNATE_IMMUNE_CELL_Cytosol map → map IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map