Protein SMAD2 map

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
CASCADE:TGFB
CASCADE:IL12
CASCADE:IL18
PMID:16713975
SMAD2, SMAD3 and SMAD4 participate in suppression of TBX21 (T-BET) promoter activity downstream of TGFB.
costimulation of NK cells with IL-12 and IL-18 downregulated SMAD2 transcript.
PMID:21042762
Inhibition of TGF-ß signalinginduced phenotypic maturation of BM-DCs and human DCs and improved their abilities to produce IL-12 in a dose-dependent manner via SMADs.
PMID:22331441
Smad2/3 inhibited IFN-β production by suppressing IRF3 transcriptional activity.
Smad2/3 somehow suppresses IRF3 phosphorylation in macrophages
Smad2 and Smad3 negatively regulate iNOS induction in macrophages by suppressing multiple steps in the IRF3-IFN-β-STAT1 pathway

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SMAD2@INNATE_IMMUNE_CELL_Cytosol map
  2. SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SMAD2|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SMAD2@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol map + SMAD4@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
  3. rSMAD2@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IL12*@INNATE_IMMUNE_CELL_Cytosol map → map IL12*@default map
  2. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  3. gARG1@INNATE_IMMUNE_CELL_Cytosol map → map rARG1@INNATE_IMMUNE_CELL_Cytosol map
  4. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
  5. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
  6. IRF3@INNATE_IMMUNE_CELL_Cytosol map → map IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map