Protein TBX21 map

Identifiers
HUGO:TBX21

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSTIMULATORY

References
 NATURAL_KILLER  map
 MACROPHAGE  map
 DENDRITIC_CELL  map
CASCADE:TGFB
CASCADE:Fc_gamma_RIII
CASCADE:IL2
CASCADE:IL15
CASCADE:IL18
CASCADE:IL12
CASCADE:IL21
CASCADE:IFNG
PMID:10761931, PMID:12055627, PMID:18768831
The pattern of T-bet expression correlates well with the production of IFNG in NK cells.
The induction of T-bet expression and secretion of IFNγ in NK cells that produce IFNγ
exists only upon treatment with IL-2 and IL-12 and CD16 pathway activation..
T-bet regulates IFNG expression in NK cells, probably via chromatin remodeling.
PMID:14614857
T-bet expression was approximately 4-fold reduced in GATA-3 deficient NK cells compared to controls, while Hlx expression was about 10-fold reduced.
PMID:18768831
TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells.
SMAD3 downstream of TGFB inhibits expression TBX21 (T-BET). TBX21 is involeved in IFNG gene activation.
PMID:15084276
T-bet is a key factor in the terminal maturation and peripheral homeostasis of NK and Vα14i NKT cells.
Granzyme B, perforin and Runx1 are direct and positievly regulated targets of TBX21 (T-BET) in NK cells.
 20675595 
Tbet overexpression in Dcs induces their antitumor abilities ;
PMID:12802010
T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells
(positive feedback)
PMID:16410834
T-bet regulates the production of proinflammatory cytokine IL-1α and chemokines macrophage inflammatory protein-1α (MIP-1α) and thymus- and activation-related chemokine (TARC) by DCs.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TBX21@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rTBX21@INNATE_IMMUNE_CELL_Cytosol map → map TBX21@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gHLX@INNATE_IMMUNE_CELL_Cytosol map → map rHLX@INNATE_IMMUNE_CELL_Cytosol map
    2. CCL3@INNATE_IMMUNE_CELL_Cytosol map → map CCL3@default map
    3. gGZMB@INNATE_IMMUNE_CELL_Cytosol map → map rGZMB@INNATE_IMMUNE_CELL_Cytosol map
    4. IL1A@INNATE_IMMUNE_CELL_Cytosol map → map IL1A@default map
    5. gRUNX1@INNATE_IMMUNE_CELL_Cytosol map → map rRUNX1@INNATE_IMMUNE_CELL_Cytosol map
    6. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
    7. gPRF1@INNATE_IMMUNE_CELL_Cytosol map → map rPRF1@INNATE_IMMUNE_CELL_Cytosol map