RNA mRNA

---

Modifications:
Participates in complexes:
In compartment: Cell membrane

1. m7GTP:​mRNA@Cell membrane
2. eIF4E:​m7GTP:​mRNA@Cell membrane
3. CBC:​EJC:​m7GTP:​mRNA@Cell membrane
4. 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
5. eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
6. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane
7. SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
8. eIF4A:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
9. Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
10. Mnk1/2:​eIF4E|​S209_pho:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
11. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
12. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
13. eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
14. Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
15. 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane
16. CBC:​EJC:​S6K1|​T229_pho|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​SKAR|​S383_pho|​S385_pho:​m7GTP:​mRNA@Cell membrane
17. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
18. ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
19. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
20. eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
21. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
22. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
23. PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
24. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
25. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
26. PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane

Participates in reactions:
As Reactant or Product:

1. eIF4E@Cell membrane + m7GTP:​mRNA@Cell membrane → eIF4E:​m7GTP:​mRNA@Cell membrane
2. eIF4E:​m7GTP:​mRNA@Cell membrane + eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane → eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
3. eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + eIF4A@Cell membrane → eIF4A:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
4. eIF4A:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + eIF4B|​S422_pho@Cell membrane → eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
5. eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + eIF3@Cell membrane → eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
6. PABP@Cell membrane + eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane → PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
7. 4EBP-1@Cell membrane + eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
8. Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane → Mnk1/2:​eIF4E|​S209_pho:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
9. eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + Mnk1/2@Cell membrane → Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
10. S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3@Cell membrane + 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane
11. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
12. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
13. Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
14. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
15. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho|​active@Cell membrane
16. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
17. PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​eIF3:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane → 5'cap-eIF4F-eIF4B-eIF3-PABP:​eIF2-GTP_Met-tRNAi_40S@Cell membrane
18. PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 5'cap-eIF4F-eIF4B-eIF3-PABP:​eIF2-GTP_Met-tRNAi_40S@Cell membrane
19. CBC:​EJC:​m7GTP:​mRNA@Cell membrane + S6K1|​T229_pho|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​SKAR|​S383_pho|​S385_pho@Cell membrane → CBC:​EJC:​S6K1|​T229_pho|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​SKAR|​S383_pho|​S385_pho:​m7GTP:​mRNA@Cell membrane
20. CBC:​EJC:​S6K1|​T229_pho|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​SKAR|​S383_pho|​S385_pho:​m7GTP:​mRNA@Cell membrane → mRNA translation@Cell membrane
21. CBP20:​CBP80@Cell membrane + m7GTP:​mRNA@Cell membrane → CBC:​EJC:​m7GTP:​mRNA@Cell membrane
22. EJC@Cell membrane + m7GTP:​mRNA@Cell membrane → CBC:​EJC:​m7GTP:​mRNA@Cell membrane
23. 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane
24. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
25. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane → eIF4E:​m7GTP:​mRNA@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
26. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
27. SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → mRNA translation@Cell membrane
28. SF2/ASF:​mTOR@Cell membrane + 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
29. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
30. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
31. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
32. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane + ?:​PP2A:​SF2/ASF@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
33. mTOR@Cell membrane + 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
34. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
35. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
36. ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → mRNA translation@Cell membrane

As Catalyser:

1. eIF4E:​m7GTP:​mRNA@Cell membrane + eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane → eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
2. Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane → Mnk1/2:​eIF4E|​S209_pho:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
3. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
4. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
5. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
6. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
7. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
8. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane