Protein FLT3LG map

Identifiers
HUGO:FLT3LG

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
 DENDRITIC_CELL  map
CASCADE:FLT3LG
PMID:10477595, PMID:9268501, PMID:8920882
The cytokine FLT3 ligand (FL) enhances dendritic cell (DC) generation and differentiation.
PMID:10477595
FL induces Ag-presenting ability of DCs.
FL induced a high level of NF-κB nuclear translocation and specific DNA binding
VEGF inhibited FL-inducible activation of transcription factor NF-κB.
PMID:14670306
STAT3 is required for Flt3L-dependent dendritic cell differentiation.
9176488 
Flt3L treatment not only induced complete tumor regression in a significant proportion of mice, but also decreased tumor growth rate in the remaining mice. Probabli via DC activation.
PMID:16418395
Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development.
PMID:8920882
Daily injection of human Flt3 ligand (Flt3L) into mice results in a dramatic numerical increase in cells co-expressing the characteristic DC markers-class II MHC, CD11c, DEC205, and CD86.
FLT3L induces PU.1 and STAT3 mRNA expression in DC progenitors and downregulates GATA1 mRNA expression.
PMID:25215878
FLT3L partially antagonized IL-10-mediated inhibition on DCs function and downregulates IL10 mRNA expression in DCs
PMID:10477595, PMID:8920882,  PMID:25215878
FLT3L induces Ag-presenting ability of Dcs. Probably via induction of surface expression of class II MHC and CD86 and also expression of CD83, a and CD80 and was significantly enhanced by the FLT3L
Daily injection of human Flt3 ligand (Flt3L) into mice results in a dramatic numerical increase in cells co-expressing the characteristic DC markers CD11c, DEC205.

Modifications:
In compartment: default
  1. FLT3LG@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. FLT3:​FLT3LG@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. FLT3LG@default map + FLT3@INNATE_IMMUNE_CELL_Membrane map → map FLT3:​FLT3LG@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CD11c*@INNATE_IMMUNE_CELL_Cytosol map → map CD11c*@INNATE_IMMUNE_CELL_Membrane map
  2. rLY75@MARKERS_DC map → map LY75@MARKERS_DC map
  3. rCD11c*@MARKERS_DC map → map CD11c*@MARKERS_DC map
  4. gSTAT3@INNATE_IMMUNE_CELL_Cytosol map → map rSTAT3@INNATE_IMMUNE_CELL_Cytosol map
  5. NFkB*@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  6. CD80@INNATE_IMMUNE_CELL_Cytosol map → map CD80@INNATE_IMMUNE_CELL_Membrane map
  7. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  8. CD83@INNATE_IMMUNE_CELL_Cytosol map → map CD83@INNATE_IMMUNE_CELL_Membrane map
  9. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map → map CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane map
  10. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  11. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map
  12. gGATA1@INNATE_IMMUNE_CELL_Cytosol map → map rGATA1@INNATE_IMMUNE_CELL_Cytosol map
  13. gSPI1@INNATE_IMMUNE_CELL_Cytosol map → map rSPI1@INNATE_IMMUNE_CELL_Cytosol map