Complex IL2RG:IL4:IL4R:JAK1:JAK2:JAK3 map
Complex composition:

  1. JAK2 map
  2. JAK1 map
  3. JAK3 map
  4. IL4 map
  5. IL4R map
  6. IL2RG map

IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL2RG:IL4:IL4R:JAK1:JAK2:JAK3

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
CASCADE:IL4

References
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4Rα and common gamma-chain (IL-2Rγ);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:20510870
Type I IL-4 receptors is assosiated with Jak1,JAK2 and JAK3. IL-4Ra associates with JAK1, JAK2 and gammaC with JAK3.
PMID:23124025
IL4 binding induces Jak1 phosphorylation (but not Jak2, JAK3, or TYK2).

IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL2RG:IL4:IL4R:JAK1:JAK2:JAK3

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
 MACROPHAGE  map
 MDSC  map
CASCADE:IL4

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  2. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL2RG:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK3@INNATE_IMMUNE_CELL_Cytosol map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  2. IL4@default map + IL2RG:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK3@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gTIMP3@INNATE_IMMUNE_CELL_Cytosol map → map rTIMP3@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. IRS2@INNATE_IMMUNE_CELL_Cytosol map → map IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  6. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  7. gIL18@INNATE_IMMUNE_CELL_Cytosol map → map rIL18@INNATE_IMMUNE_CELL_Cytosol map
  8. gINHBA@INNATE_IMMUNE_CELL_Cytosol map → map rINHBA@INNATE_IMMUNE_CELL_Cytosol map
  9. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map