Protein SMAD4 map

Identifiers
HUGO:SMAD4

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:TGFB
PMID:11792802, PMID:12809600
The canonical TGFB signalling pathway involves phosphorylation of the carboxy-terminal serine residue of the internal modulator SMAD proteins, SMAD2 or SMAD3, by the activated receptors. This phosphorylation induces oligomerization of SMAD2 or SMAD3 with SMAD4, which is necessary for nuclear translocation.
PMID:16713975
SMAD2, SMAD3 and SMAD4 participate in suppression of TBX21 (T-BET) promoter activity downstream of TGFB.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SMAD4@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SMAD2|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
  2. SMAD3|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol map + SMAD4@INNATE_IMMUNE_CELL_Cytosol map → map SMAD3|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
  2. SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol map + SMAD4@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IL12*@INNATE_IMMUNE_CELL_Cytosol map → map IL12*@default map
  2. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  3. gARG1@INNATE_IMMUNE_CELL_Cytosol map → map rARG1@INNATE_IMMUNE_CELL_Cytosol map
  4. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
  5. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
  6. IRF3@INNATE_IMMUNE_CELL_Cytosol map → map IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map