Protein MIF map

Identifiers
HUGO:MIF

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS MODULE:EFFECTOR_INHIBITION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION

References
 MACROPHAGE  map
 MDSC  map
 NATURAL_KILLER  map
CASCADE:MIF
CASCADE:TNF
CASCADE:IFNG
CASCADE:IL4
CASCADE:IL13
CASCADE:TLR2_4
PMID:9637476, PMID:10878343
MIF prevented the release of perforin granules by NK cells but not CTLs.
Tumor cells produce Macrophage Migration-Inhibitory Factor to Prevent Lysis by NK Cells.
PMID:18490733
MIF inhibits NK cell activity through a transcriptional down-regulation of NKG2D
PMID:16283355, PMID:12803886
MIF upregulates expression of TLR4 in macrothages via PU.1 (SPI1) activation
PMID:12782713
MIF signal transduction initiated by binding to CD74.
PMID:23390297
MIF deficiency or small-molecule inhibition reduces splenic MDSC immune suppression in tumor-bearing mice
PMID:8195715
TNF and INFG induce MIF secretion in macrophages, TLR4 signaling induces MIF expression.
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD23

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MIF@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. MIF@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD74:​MIF@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. rMIF@INNATE_IMMUNE_CELL_Cytosol map → map MIF@INNATE_IMMUNE_CELL_Cytosol map
  2. MIF@INNATE_IMMUNE_CELL_Cytosol map → map MIF@default map
  3. MIF@default map + CD74@INNATE_IMMUNE_CELL_Membrane map → map CD74:​MIF@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
  2. gMRC1@MARKERS_MACROPHAGE map → map rMRC1@MARKERS_MACROPHAGE map
  3. gSTAB1@MARKERS_MACROPHAGE map → map rSTAB1@MARKERS_MACROPHAGE map
  4. gFCER2@MARKERS_MACROPHAGE map → map rFCER2@MARKERS_MACROPHAGE map
  5. CD11c*@INNATE_IMMUNE_CELL_Cytosol map → map CD11c*@INNATE_IMMUNE_CELL_Membrane map
  6. PRF1@SECRETORY_GRANULE map → map PRF1@default map
  7. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol map → map ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  8. gNKG2D*@INNATE_IMMUNE_CELL_Cytosol map → map rNKG2D*@INNATE_IMMUNE_CELL_Cytosol map
  9. CD80@INNATE_IMMUNE_CELL_Cytosol map → map CD80@INNATE_IMMUNE_CELL_Membrane map
  10. CD86@INNATE_IMMUNE_CELL_Cytosol map → map CD86@INNATE_IMMUNE_CELL_Membrane map
  11. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  12. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
  13. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  14. gMMP9@INNATE_IMMUNE_CELL_Cytosol map → map rMMP9@INNATE_IMMUNE_CELL_Cytosol map
  15. gMHC class II*@INNATE_IMMUNE_CELL_Cytosol map → map rMHC class II*@INNATE_IMMUNE_CELL_Cytosol map
  16. gVEGFA@INNATE_IMMUNE_CELL_Cytosol map → map rVEGFA@INNATE_IMMUNE_CELL_Cytosol map
  17. SPI1@INNATE_IMMUNE_CELL_Cytosol map → map SPI1@INNATE_IMMUNE_CELL_Cytosol map
  18. gIRF5@INNATE_IMMUNE_CELL_Cytosol map → map rIRF5@INNATE_IMMUNE_CELL_Cytosol map
  19. gPTGS2@INNATE_IMMUNE_CELL_Cytosol map → map rPTGS2@INNATE_IMMUNE_CELL_Cytosol map
  20. PGE2@INNATE_IMMUNE_CELL_Cytosol map → map PGE2@default map