Identifiers
Fanconi anemia, complementation group M
HUGO:FANCM HGNC:23168 ENTREZ:57697 UNIPROT:Q8IYD8 GENECARDS:FANCM REACTOME:229316 KEGG:57697 ATLASONC:GC_FANCM WIKI:FANCM

Maps_Modules
 dnarepair 
 dnarepair 
 dnarepair 
 dnarepair 

References
PMID:19686080, PMID:19622404, PMID:18931676, PMID:23444773
FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex
PMID:19622404
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase
PMID:19282663, PMID:19622404
Link between Fanconi and NER
PMID:22615860
Fanconi and cross-linking agents
PMID:21948210
FA core complex regulates REV1 and activated TLS
PMID:22266823

References
d_re194( dnarepair  ):
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080
d_re195( dnarepair  ):
FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156

References
d_re14( dnarepair  ):
Link between Fanconi and NER
PMID:22615860
d_re194( dnarepair  ):
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080
d_re199( dnarepair  ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
d_re252( dnarepair  ):
Requirement for functional DNA polymerase eta in genome-wide repair by NER of UV-induced DNA damage during S phase:
PMID:20457011

1. FANCM@default
2. FANCM|​pho@default

1. FAAP24*:​FANCM@default
2. ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default
3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default
4. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default

1. FAAP24*@default + FANCM@default → FAAP24*:​FANCM@default
2. FANCA|​pho:​FANCG|​S7_pho@default + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@default + FAAP24*:​FANCM@default + FAAP100*:​FANCB:​FANCL@default + BLM@Nucleus + HES1@default + FAAP20*@default → BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default
3. FANCM@default → FANCM|​pho@default
4. FANCM|​pho@default → degraded
5. HCLK2*@default + FAAP24*@default + FANCM@default + ATR|​pho|​active@Nucleus → ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default
6. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default + TOP3A@default + RPA1:​RPA2:​RPA3@default → BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default

1. S phase@default → G2 phase@default
2. G2 phase@default → M phase@default
3. gTC-NER_DNA_st2*@Nucleus → gTC-NER_GG-NER_DNA_st3*@Nucleus
4. gFanconi_DNA_st1*@Nucleus → gFanconi_DNA_st2*@Nucleus
5. gFanconi_DNA_st2*@Nucleus → gFanconi_DNA_st3*@Nucleus
6. FANCD2|​pho@default → FANCD2|​K561_ubi|​pho@default
7. FANCI|​pho@default → FANCI|​K523_ubi|​pho@default
8. gFanconi_DNA_st4*@Nucleus → gFanconi_DNA_st5*@Nucleus
9. FANCD2@default → FANCD2|​pho@default
10. FANCD2|​K561_ubi|​pho@default + MRE11*:​NBS1*|​S343_pho:​RAD50@default + ATR|​pho|​active@Nucleus → ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default
11. gGG-NER_DNA_st1*@Nucleus → gGG-NER_DNA_st2*@Nucleus
12. gTLS_DNA_st1*@Nucleus → gTLS_DNA_st2*@Nucleus